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Cisplatin ototoxicity: the importance of baseline audiometry
https://pubmed.ncbi.nlm.nih.gov/10362343/#:~:text=The%20role%20and%20optimal%20use%20of%20audiometry%20in,then%20was%20conducted%20in%2053%20of%20these%20patients.
Cisplatin ototoxicity: the importance of baseline audiometry
https://pubmed.ncbi.nlm.nih.gov/10362343/
Abstract The role and optimal use of audiometry in monitoring for cisplatin ototoxicity are incompletely defined. Audiograms were obtained from 217 patients before treatment with cisplatin-based chemotherapy for cancers of the esophagus, lung, or head and neck. Posttreatment audiometry then was conducted in 53 of these patients.
Ototoxicity in patients receiving cisplatin: importance of ...
https://pubmed.ncbi.nlm.nih.gov/7198012/
Fifteen patients developed significant audiometric abnormality after a mean cumulative dose of 203 mg/m2. Ototoxicity was more severe with higher cumulative doses and higher individual doses, and was most marked in those patients receiving bolus injections. Loss of perception of higher frequencies was most common.
Insight into the current practice of ototoxicity ...
https://pubmed.ncbi.nlm.nih.gov/33766142/
Prior to treatment, 196 (51.7%) patients were counseled regarding the ototoxic nature of cisplatin and 92 (24.3%) patients had a pretreatment audiogram. During treatment, 91 (24%) patients had documented otologic complaints. Only 17 patients (4.5%) patients had an audiogram ordered during their cisplatin treatment period. 130 (34.3%) patients ...
Cisplatinum ototoxicity in children, long-term follow up
https://pubmed.ncbi.nlm.nih.gov/20846503/
Thirty-three (7/21) of audiograms worsened on long-term follow up. Questionnaire revealed 70% subjective hearing loss with 40% requiring hearing aids. Conclusion: Ototoxicity after platinum chemotherapy can present or worsen years after completion of therapy. Therefore, we recommend long-term follow up. MeSH terms Adolescent Age Distribution
Cisplatin Ototoxicity: The Importance of Baseline ...
https://journals.lww.com/amjclinicaloncology/Abstract/1999/06000/Cisplatin_Ototoxicity__The_Importance_of_Baseline.20.aspx
Abstract The role and optimal use of audiometry in monitoring for cisplatin ototoxicity are incompletely defined. Audiograms were obtained from 217 patients before treatment with cisplatin-based chemotherapy for cancers of the esophagus, lung, or head and neck. Posttreatment audiometry then was conducted in 53 of these patients.
The Role of Audiometry prior to High-Dose Cisplatin in ...
https://pubmed.ncbi.nlm.nih.gov/28511189/
Forty-two participants (41%) did not commence high-dose cisplatin because of baseline audiometric alterations. Of 61 patients treated with high-dose cisplatin, 40 (66%) showed marked ototoxicity at the end of treatment. The mean hearing loss between initial and final audiometries showed a hearing loss at 4 and 8 kHz in both ears (p = 0.002).
Cisplatin-Associated Ototoxicity: A Review for the Health ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223030/
Cisplatin-associated ototoxicity usually manifests as irreversible, progressive [8], bilateral, high frequency sensorineural hearing loss [29] with tinnitus [30].
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